Experimental development in biotechnology

Experimental development in biotechnology.

One of the main areas of activity of the company is related to developments in biotechnology. Starting from 2012, investment in research and development has been made, to create the technical basis for in vitro multiplication of eukaryotic cells, using automated systems and developing technological processes related to cell multiplication. Using this basis, three sub-lines have been created: acquisition of biologically active substances released during the cell culture process and accumulated in the culture medium; large-volume cell multiplication for potential clinical use; development of automated cell culture systems.

Acquisition of biologically active substances

During their lifespan, cells release many different biologically active substances that serve as signals or ensure the functioning and communication of tissues, or as a reaction to environmental impacts. When cultivating cells in a controlled environment, it is possible to simulate certain circumstances that force the specific cell population to release biologically active substances. Using this principle, it is possible to acquire biologically active substances that can be used for skin regeneration products.

In vitro cell multiplication

As new treatment methods based on the use of human cells and tissue developed, the industry faced the problem of availability of the cells necessary for treatment. Cell volumes acquired from patient biopsies were often insufficient to expect efficient therapeutic results, and there was much variability in the volume, thus making evaluation of clinical efficiency more difficult. In order to provide certain concentrations and perform procedures that consist of several stages, a demand appeared within the industry for equipment for in vitro multiplication of various cells.

The main challenges were the creation of processes that are as similar as possible to the processes within the human body, as well as the acquisition of a high-quality product in sufficient volumes.

Development of cell cultivation systems

Automated cell culture systems are a significant prerequisite for the development of products and acquisition of raw materials. Historically, cultivation of eukaryotic cells was carried out using specialized laboratory vessels, that could not provide sufficient protection against infections and were relatively inefficient due to their design. As the demand for large-volume cell multiplication appeared, solutions were sought that could significantly increase cultivation surfaces in a low volume and decrease contamination risks. The company carries out development related to conceptual solutions and process automation for reactor systems used in large volume adherent cell.